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Dantellah Group

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147670 Zip HOT!

Using the polymerase chain reaction to study mRNA expressed in human epithelial tumor cells, Dorow et al. (1993) identified a member of a new family of protein kinases. The catalytic domain of these kinases had amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. Dorow et al. (1993) isolated clones representing 2 members of this new family from a human colonic epithelial cDNA library. The predicted amino acid sequence revealed that, in addition to their unusual nature of the kinase catalytic domains, they contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. Because they possess domains associated with proteins from 2 distinct functional groups, these kinases were referred to as mixed-lineage kinases (MLK) 1 and 2. MLK1 mRNA was found to be expressed in epithelial tumor cell lines of colonic, breast, and esophageal origin. The similarity score with MLK1 varied from 73 down to 61 for the following tyr PKs; ROS (165020), ABL (189980), EGFR (131550), SRC (190090), TRK (191315), PDGFR (173410, 173490), INSR (147670). The similarity score with MLK1 was 63 for RAF (164760) and 52 for MOS (190060).

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